Fig. 3.

Effect of ITI-214 on performance of rats in the conditioned avoidance response (CAR) paradigm. The conditioned avoidance response was measured in rats treated with ITI-214 (1 mg/kg, po, −60 min) alone or in combination with the antipsychotic medication, risperidone (0.2 or 0.8 mg/kg ip, −20 min). Data are shown as medians ± semi-interquartile range based on repeated observations of the same eight animals rotated over all treatment groups serving as their own controls in a counterbalanced change-over design. **p < 0.001 compared with vehicle alone (Wilcoxon matched-pairs signed-ranks test); ns not significant compared with vehicle alone