Table 1. Association of p.R179X in RNF186 with ulcerative colitis.

Study	Data type	UC		Controls		Control MAF (%)	P	OR
		179 ×	R179	179 ×	R179
GWASseq	Sequence (targeted)	0	1,774	6	1,828	0.33
Finland	Sequence (exome)	0	1,016	23	16,223	0.14
Screen	—	0	2,790	29	18,051		0.022	0
US+Canada	Exome chip	4	6,354	21	12,883	0.16
UK	Sequencing	2	3,854	10	7,294	0.14
Sweden	Exome chip	2	1,518	45	10,813	0.41
Belgium	Genotyping	0	1,696	0	1,764	0.00
Germany	Genotyping	1	2,035	7	4,399	0.16
Dutch	Genotyping	1	1,133	8	4,164	0.19
Italy	Genotyping	0	0	2	1,914	0.10
Iceland	Sequencing+imputation	7	2,899	4,130	525,358	0.78
			N cases 1,453	N controls 264,744	MAF=0.78%
Replication							8.69 × 10−6	0.33 (0.20–0.55)
Combined (screen +replication)							6.89 × 10−7	0.30 (0.19–0.50)

Screen+replication P value is computed using Mantel–Haenszel χ²-test with continuity correction.