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. 2016 Aug 9;7:12451. doi: 10.1038/ncomms12451

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The marker SNP is shown in purple and the r² values for the other SNPs are indicated by different colours. Correlations were estimated using data from the 1000 Genomes Project. Genes within the region of interest are annotated and are indicated by arrows. The blue lines indicate the recombination rates in centimorgans (cM) per megabase (Mb). Circles represent the location and –log₁₀ (P_Trend values) of each variant. The –log₁₀P_Trend values of the marker SNPs are shown for the GWAS (G), the combined validation study (CV) and the total combined study (CA).