Table 3. Druggable mutations observed in samples assayed with targeted sequencing.
| Sample | WGS | Gene | Amino acid change | Baseline VAF | Surgical VAF | Ki67 BL | Ki67 PT | Ki67 response |
|---|---|---|---|---|---|---|---|---|
| 451180 | — | ERBB2 | p.R599C | 4.59 | 0 | 0.3 | 0.125 | Resistant |
| 917386 | BRC14 | ERBB2 | p.V777L | 26.67 | 31.55 | 0.442 | 0.012 | Sensitive |
| 148037 | — | ERBB2 | p.780in_frame_insGSP | 2.67 | 12.35 | 0.003 | 0.001 | Sensitive |
| 963465 | — | ERBB2 | p.S157F | 0 | 7.21 | 0.121 | 0.015 | Sensitive |
| 451180 | — | ESR1 | p.E380Q | 1.19 | 3.9 | 0.3 | 0.125 | Resistant |
| 306707 | — | ESR1 | p.K481N | 14.17 | 39.71 | 0.266 | 0.117 | Resistant |
| 375938 | BRC22 | ESR1 | p.D538G | 0 | 11.93 | 0.008 | 0 | Sensitive |
| 255394 | BRC39 | PIK3CA | p.P104R | 52.73 | 23.81 | 0.356 | 0.124 | Resistant |
| 702554 | — | PIK3CA | p.N345K | 29.41 | 34.09 | 0.6 | 0.8 | Resistant |
| 229684 | — | PIK3CA | p.G364R | 34.33 | 29.49 | 0.265 | 0.002 | Sensitive |
| 629051 | — | PIK3CA | p.E418K | 35.06 | 41.54 | 0.086 | 0.01 | Sensitive |
| 228281 | — | PIK3CA | p.C420R | 22.58 | 29.71 | 0.327 | 0.015 | Sensitive |
| 169316 | BRC38 | PIK3CA | p.E542K | 0 | 28.95 | 0.162 | 0.471 | Resistant |
| 434673 | BRC42 | PIK3CA | p.E542K | 10.17 | 4.55 | 0.081 | 0.022 | Sensitive |
| 144029 | — | PIK3CA | p.E545K | 16.67 | 28.57 | 0.217 | NA | Resistant |
| 306707 | — | PIK3CA | p.E545K | 10.68 | 38.05 | 0.266 | 0.117 | Resistant |
| 629051 | — | PIK3CA | p.E545Q | 39.58 | 29.89 | 0.086 | 0.01 | Sensitive |
| 228281 | — | PIK3CA | p.E545K | 84.13 | 26.28 | 0.387 | 0.045 | Sensitive |
| 412952 | BRC39 | PIK3CA | p.N1044K | 41.11 | 19.75 | 0.356 | 0.124 | Resistant |
| 255394 | BRC21 | PIK3CA | p.H1047R | 0 | 19.28 | 0.058 | 0.019 | Sensitive |
| 441655 | BRC40 | PIK3CA | p.H1047R | 27.18 | 27.14 | 0.076 | 0.008 | Sensitive |
| 956936 | BRC37 | PIK3CA | p.H1047R | 55.52 | 66.25 | 0.76 | 0.308 | Resistant |
| 303279 | BRC10 | PIK3CA | p.H1047R | 50 | 36.27 | 0.492 | 0.035 | Sensitive |
| 632762 | — | PIK3CA | p.H1047R | 48.84 | 19.21 | 0.388 | 0.268 | Resistant |
| 808150 | BRC50 | PIK3CA | p.H1047L | 48.26 | 45.18 | 0.195 | 0.104 | Resistant |
| 629834 | — | PIK3CA | p.H1047R | 60 | 33.73 | 0.177 | 0.009 | Sensitive |
| 895779 | — | PIK3CA | p.H1047R | 12.04 | 21.77 | 0.112 | 0.029 | Sensitive |
| 641677 | BRC15 | PIK3CA | p.H1047R | 37.78 | 27.17 | 0.238 | 0.01 | Sensitive |
| 384803 | BRC24 | PIK3CA | p.H1047R | 35.63 | 24.21 | 0.152 | 0.155 | Resistant |
| 526430 | BRC18 | PIK3CA | p.H1047R | 23.64 | 23.58 | 0.125 | 0 | Sensitive |
| 767881 | — | PIK3CA | p.H1047R | 54.29 | 32.07 | 0.091 | 0.162 | Resistant |
| 411144 | — | PIK3CA | p.H1047R | 22.35 | 2.99 | 0.3 | 0.063 | Sensitive |
| 251239 | — | PIK3CA | p.H1047R | 45.65 | 45.45 | 0.53 | 0.453 | Resistant |
| 439295 | — | PIK3CA | p.G1049R | 23.53 | 22.16 | 0.154 | 0.077 | Sensitive |