Figure 2. Intracellular metabolism of exogenous prodrug-delivered succinate.

(a) TCA cycle intermediates in peripheral blood mononuclear cells after 20 min incubation with or without rotenone and NV189 quantified using capillary electrophoresis mass spectrometry, n=4. Data presented as mean and s.d. (b) Fraction of [¹³C] isotope labelled carbons in TCA cycle intermediates and related metabolites in human platelets incubated with [1, 2, 3, 4-¹³C₄]NV118 for 7.5, 15, 30, 120 or 240 min. Mean of n=2. 2-OG, 2-oxoglutaric acid.