Table 2.
On-Study Management and Clinical Outcomes for Liberal vs Conservative Fluid Management by Baseline Biomarker Concentration
| Variable | B-Type Natriuretic Peptide |
|||||
|---|---|---|---|---|---|---|
| Above Median |
P Value | Below Median |
P Value | |||
| Liberal (n = 146) |
Conservative (n = 167) |
Liberal (n = 163) |
Conservative (n = 150) |
|||
| On-study management | ||||||
| Cumulative fluid balance, L | 7.0 ± 10.5 | 1.2 ± 11.0 | < .001 | 6.9 ± 8.9 | –0.3 ± 9.0 | < .001 |
| Total furosemide dose, mg | 132 ± 228 | 409 ± 485 | < .001 | 130 ± 232 | 553 ± 642 | < .001 |
| Clinical outcomes | ||||||
| Death by 60 d, No. (%) | 41 (28) | 36 (22) | .18 | 32 (20) | 27 (18) | .71 |
| Ventilator-free days | 12.6 ± 10.4 | 15.9 ± 10.4 | .001 | 13.9 ± 9.7 | 15.7 ± 10.1 | .04 |
| Duration of mechanical ventilation, overall, d | 14.4 ± 14.8 | 10.7 ± 12.2 | < .001 | 13.8 ± 12.0 | 12.3 ± 12.8 | .04 |
| Duration of mechanical ventilation, among survivors, d | 14.4 ± 16.2 | 10.5 ± 12.9 | .001 | 12.9 ± 11.2 | 11.4 ± 12.7 | .02 |
| ICU-free days | 11.2 ± 9.9 | 14.7 ± 10.0 | < .001 | 12.8 ± 9.2 | 13.8 ± 9.6 | .24 |
| ICU length of stay, overall, d | 16.4 ± 14.4 | 11.7 ± 10.1 | < .001 | 15.5 ± 13.7 | 13.8 ± 11.5 | .19 |
| ICU length of stay, among survivors, d | 16.2 ± 15.2 | 11.4 ± 10.2 | < .001 | 14.9 ± 13.7 | 13.1 ± 11.3 | .16 |
| Variable | Aldosterone |
|||||
|---|---|---|---|---|---|---|
| Above Median |
P Value | Below Median |
P Value | |||
| Liberal (n = 149) |
Conservative (n = 167) |
Liberal (n = 162) |
Conservative (n = 154) |
|||
| On-study management | ||||||
| Cumulative fluid balance, L | 6.0 ± 8.7 | 1.1 ± 10.9 | < .001 | 7.9 ± 10.3 | –0.3 ± 9.0 | < .001 |
| Total furosemide dose, mg | 114 ± 186 | 487 ± 593 | < .001 | 145 ± 262 | 463 ± 538 | < .001 |
| Clinical outcomes | ||||||
| Death by 60 d, No. (%) | 25 (17) | 37 (22) | .23 | 48 (30) | 29 (19) | .03 |
| Ventilator-free days | 14.3 ± 9.6 | 14.4 ± 10.6 | .47 | 12.5 ± 10.3 | 17.1 ± 9.8 | < .001 |
| Duration of mechanical ventilation, overall, d | 13.0 ± 10.9 | 12.5 ± 13.7 | .06 | 15.0 ± 15.2 | 10.3 ± 11.0 | < .001 |
| Duration of mechanical ventilation, among survivors, d | 12.9 ± 11.2 | 12.3 ± 14.1 | .04 | 14.1 ± 15.83 | 9.5 ± 11.2 | < .001 |
| ICU-free days | 12.9 ± 9.1 | 13.0 ± 10.1 | .51 | 11.2 ± 9.9 | 19.5 ± 9.5 | < .001 |
| ICU length of stay, overall, d | 14.4 ± 11.0 | 13.7 ± 12.2 | .12 | 17.3 ± 16.2 | 11.6 ± 9.4 | < .001 |
| ICU length of stay, among survivors, d | 14.3 ± 10.6 | 13.5 ± 12.3 | .08 | 16.7 ± 17.4 | 10.8 ± 8.7 | .002 |
Data are given as mean ± SD or as otherwise indicated.