Table 2.
Effect of CPAP Treatment on Cardiovascular Biomarkers, Intent to Treat (Change of Biomarker From Baseline)
| Outcome | Sham (n = 71) | CPAP (n = 72) | P Value |
|---|---|---|---|
| Oxidative stress/inflammation biomarkers | |||
| F2-isoprostanes/Cra | −0.02 (−0.12 to 0.10) | −0.08 (−0.18 to 0.03) | .38 |
| Myeloperoxidase, pmol/L | −3.33 (−17.02 to 10.37) | −5.15 (−18.65 to 8.35) | .85 |
| Lipoprotein (a), mg/dL | 0.00 (−0.01 to 0.02) | 0.00 (−0.01 to 0.02) | .99 |
| Oxidized LDL, U/L | −1.38 (−2.69 to −0.07) | −1.34 (−2.64 to −0.03) | .96 |
| Paraoxonase, U/mL | 1.37 (−55.91 to 58.64) | −17.02 (−73.03 to 38.99) | .65 |
| Aryl esterase, nmol/min/mL | −0.92 (−6.47 to 4.63) | −5.74 (−11.16 to −0.31) | .22 |
| sIL-6Ra | 0.02 (−0.02 to 0.06) | −0.04 (−0.08 to −0.01) | .019 |
| IL-6 (pg/mL) | 0.29 (−0.10 to 0.68) | −0.08 (−0.46 to 0.29) | .17 |
| Arterial stiffness measures | |||
| AIx, evening, % | −0.43 (−3.87 to 3.00) | −1.79 (−5.36 to 1.78) | .59 |
| AIx, morning, % | 0.44 (−2.22 to 3.10) | −6.49 (−9.32 to −3.65) | < .001 |
| Augmentation pressure, evening, mm Hg | 0.36 (−0.90 to 1.63) | −0.18 (−1.52 to 1.15) | .56 |
| Augmentation pressure, morning, mm Hg | 0.34 (−1.03 to 1.72) | −1.46 (−2.98 to 0.07) | .085 |
| Pulse wave velocity, evening, cm/s | −0.08 (−0.57 to 0.40) | −0.30 (−0.80 to 0.20) | .55 |
| Pulse wave velocity, morning, cm/s | −0.25 (−0.82 to 0.32) | −0.42 (−1.01 to 0.16) | .68 |
| BP | |||
| SBP, evening, mm Hg | −0.95 (−3.59 to 1.69) | −0.41 (−3.03 to 2.21) | .78 |
| SBP, morning, mm Hg | 0.17 (−2.44 to 2.78) | −3.44 (−6.03 to −0.85) | .054 |
| DBP, evening, mm Hg | −0.45 (−2.52 to 1.61) | −0.83 (−2.88 to 1.22) | .80 |
| DBP, morning, mm Hg | 0.11 (−1.73 to 1.94) | −1.37 (−3.19 to 0.46) | .27 |
| Mean arterial BP, evening, mm Hg | −0.59 (−2.53 to 1.35) | −0.72 (−2.65 to 1.20) | .92 |
| Mean arterial BP, morning, mm Hg | 0.24 (−1.64 to 2.12) | −2.17 (−4.03 to −0.30) | .076 |
Results are least square means and 95% CI of absolute change from baseline, with adjustment of baseline. See Table 1 legend for expansion of abbreviations.
a
Data was log-transformed for analysis and transformed back for presentation. The findings reflect the percentage change (ie, the percent of change at week 8 to baseline values).