Table 3.
Absolute Change From Baseline: Adjusted for Baseline, Group Split by Compliant Days (≥ 4 h) ≥ 70%a
| Outcome | No. | Sham (n = 71) | CPAP Nonadherent (n = 38) | CPAP Adherent (n = 29) | P Value |
|---|---|---|---|---|---|
| Oxidative stress/inflammation markers | |||||
| F2-isoprostanes/Crb | 125 | −0.01 (−0.12 to 0.11) | −0.09 (−0.23 to 0.07) | −0.08 (−0.24 to 0.11) | .65 |
| Myeloperoxidase, pmol/L | 132 | −3.26 (−17.25 to 10.73) | −0.53 (−19.75 to 18.69) | −9.79 (−31.66 to 12.08) | .81 |
| Lipoprotein (a), mg/dL | 133 | 0.00 (−0.01 to 0.02) | 0.02 (0.00 to 0.04) | −0.02 (−0.04 to 0.01) | .040 |
| Oxidized LDL, U/L | 133 | −1.38 (−2.70 to −0.05) | −1.02 (−2.85 to 0.81) | −1.38 (−3.46 to 0.70) | .95 |
| Paraoxonase, U/mL | 129 | 1.92 (−56.46 to 60.30) | −5.89 (−85.25 to 73.46) | −33.30 (−124.9 to 58.33) | .81 |
| Aryl esterase, nmol/min/mL | 129 | −1.00 (−6.64 to 4.63) | −2.65 (−10.27 to 4.96) | −9.62 (−18.46 to −0.79) | .27 |
| sIL-6Rb | 123 | 0.02 (−0.02 to 0.06) | −0.02 (−0.08 to 0.03) | −0.06 (−0.12 to 0.00) | .066 |
| IL-6 (pg/mL) | 123 | 0.30 (−0.10 to 0.70) | −0.12 (−0.64 to 0.41) | −0.03 (−0.64 to 0.58) | .40 |
| Arterial stiffness measures | |||||
| AIx, evening | 98 | −0.38 (−3.85 to 3.09) | −1.60 (−6.25 to 3.05) | −2.78 (−8.85 to 3.30) | .77 |
| AIx, morning | 93 | 0.46 (−2.23 to 3.14)c | −6.25 (−9.97 to −2.53)d | −7.16 (−11.76 to −2.56) | .003 |
| Augmentation pressure, evening, mm Hg | 102 | 0.37 (−0.91 to 1.64) | 0.19 (−1.57 to 1.95) | −0.79 (−3.02 to 1.45) | .67 |
| Augmentation pressure, morning, mm Hg | 95 | 0.35 (−1.02 to 1.73) | −1.24 (−3.24 to 0.77) | −2.13 (−4.56 to 0.29) | .15 |
| Pulse wave velocity, evening | 87 | −0.10 (−0.59 to 0.40) | −0.31 (−1.00 to 0.37) | −0.31 (−1.22 to 0.60) | .85 |
| Pulse wave velocity, morning | 104 | −0.26 (−0.84 to 0.32) | −0.39 (−1.14 to 0.35) | −0.23 (−1.33 to 0.86) | .95 |
| BP | |||||
| SBP, evening, mm Hg | 136 | −0.88 (−3.56 to 1.80) | −0.47 (−4.25 to 3.31) | 0.80 (−3.43 to 5.03) | .80 |
| SBP, morning, mm Hg | 136 | 0.19 (−2.45 to 2.83) | −2.48 (−6.19 to 1.24) | −3.65 (−7.78 to 0.48) | .24 |
| DBP, evening, mm Hg | 136 | −0.35 (−2.39 to 1.70) | −0.45 (−3.33 to 2.42) | 0.47 (−2.72 to 3.66) | .90 |
| DBP, morning, mm Hg | 136 | 0.25 (−1.57 to 2.08) | −0.51 (−3.08 to 2.06) | −1.70 (−4.53 to 1.14) | .52 |
| Mean arterial BP, evening, mm Hg | 136 | −0.49 (−2.42 to 1.43) | −0.44 (−3.15 to 2.28) | 0.47 (−2.55 to 3.49) | .86 |
| Mean arterial BP, morning, mm Hg | 136 | 0.33 (−1.54 to 2.21) | −1.29 (−3.94 to 1.35) | −2.43 (−5.35 to 0.49) | .26 |
Results are least square means and 95% CI. See Table 1 legend for expansion of abbreviations.
Pairwise comparison: cSham differed from CPAP adherent, dCPAP nonadherent differed from CPAP adherent.
a
Groups split by compliant days (≥ 4 h) ≥ 70%.
b
Data were log-transformed for analysis, and transformed back for presentation.