Table A1.

Multivariable Analysis of Risk Factors Associated With an Increased Risk of Cardiac Event in Patients Who Proceeded to Post-AC Therapy

Characteristic	Hazard Ratio	95% CI
Age, years
≥ 60	2.755	1.237 to 6.137
50-59	1.350	0.615 to 2.964
< 50	Reference	Reference
Current or prior antihypertensive medications
Yes	1.821	0.890 to 3.725
No	Reference	Reference
LVEF at registration, %
≥ 65	Reference	Reference
55-64.9	2.908	1.361 to 6.210
50-54.9	3.975	1.329 to 11.888

NOTE. This analysis only includes variables that were found to be significant in univariable analysis. Cardiac risk score (which incorporated age and baseline LVEF) is excluded from this analysis.

Abbreviations: AC, doxorubicin plus cyclophosphamide; LVEF, left ventricular ejection fraction.