Table A4.

Decreases in LVEF by Change of Markers From Baseline Levels

Baseline Marker Change	No. of Patients/Total No. of Patients (%) With Decrease in LVEF*		P
	Yes	No
BNP normal at baseline to double postbaseline and > 40 ng/mL	3/11 (27)	3/44 (7)	.09
TnT normal at baseline to abnormal postbaseline	2/14 (14)	6/51 (12)	1.00
TnI normal at baseline to abnormal postbaseline	3/11 (27)	14/49 (29)	1.00
TnT and TnI both normal at baseline to both abnormal postbaseline	1/11 (9)	5/48 (10)	1.00
CRP normal at baseline to abnormal postbaseline	5/8 (63)	13/32 (41)	.43
TNF-α normal at baseline to abnormal postbaseline	2/14 (14)	6/51 (12)	1.00
IL-6 normal at baseline to abnormal postbaseline	0/13	3/48 (6)	1.00
IL-1β normal at baseline to abnormal postbaseline	0/13	2/46 (4)	1.00

Abbreviations: BNP, brain natriuretic peptide; CRP, C-reactive protein; IL, interleukin; LVEF, left ventricular ejection fraction; Tn, troponin; TNF, tumor necrosis factor.

^*Decrease in LVEF measure was defined as a decrease of 10% to 15% from baseline to below the lower limit of normal or a decrease in LVEF > 15%.