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. 2016 May 10;94(7):680–688. doi: 10.1038/icb.2016.36

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Copyright © 2016 Australasian Society for Immunology Inc.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Role of DC density and antigen persistence on kinapse- or synapse-driven T-cell activation. (a) T-cell contacts were simulated for distinct densities of DCs presenting a low- or high-affinity peptide. (b) Simulated CFSE profiles at 66 h analyzed for three different DC densities for DC presenting either a low- or high-affinity peptides. (c) Simulated CFSE profiles at 66 h were analyzed for an intermediate value of DC density (3000 cells/mm³) presenting either a low- or high-affinity peptide with the indicated values of antigen half-life.