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T-cell proliferation by low-affinity peptides requires long half-lives for previously collected TCR signals. (a) Scheme illustrating the integration of TCR signals collected by T cells over successive interactions. Note that the model allows for the control of TCR signal decay once T cells have detached from the DC. (b) T-cell responses were simulated for various half-lives of TCR signals. Simulated CFSE profiles at 66 h are shown.
