Table 6. Summary of HLA alleles with HCV clearance or persistence in published reports and this study.
| Associated HLA allele | Association with HCV | population (clearance or SVR/persistence or NR, if not specified) | Study |
|---|---|---|---|
| A*02 | Persistence in Caucasian; spontaneous clearance in non-Caucasians | USA (49/56) | 27 |
| SVR | Chinese (144 A*02 positive/149 A*02 negative patients) | 33 | |
| Protective | USA (11,728 HCV uninfected/5901 HCV infected) | 34 | |
| A*02:01 | Spontaneous clearance* | Chinese (231/429) | This study |
| A*02:03 | No association | Chinese (231/429) | This study |
| A*02:07 | No association | Chinese (231/429) | This study |
| B*57 | Spontaneous clearance | USA (231/444) | 23 |
| Spontaneous clearance | USA(136/622) | 25 | |
| Spontaneous clearance | USA (66/280) | 29 | |
| Spontaneous clearance | West Africa (35/37) | 30 | |
| No association | USA (79/200) | 35 | |
| No association | Chinese (231/429) | This study | |
| DQB1*03 | Spontaneous clearance | USA (49/56) | 27 |
| Protective | USA (11,728 HCV uninfected/5901 HCV infected) | 34 | |
| Protective | Japan (2,963 healthy controls/481 chronic HCV infected) | 42 | |
| DQB1*03:01 | Spontaneous clearance | USA (200/374) | 26 |
| Spontaneous clearance | Italy (49/68) | 41 | |
| Spontaneous clearance | Iran (54/63) | 38 | |
| Spontaneous clearance | Chinese (432/686) | 43 | |
| SVR | Chinese (156/87) | 43 | |
| SVR | Pakistan (150/54) | 36 | |
| Clearance | Meta-analysis | 37 | |
| Clearance | Meta-analysis | 7 | |
| DQB1*03:01 | No association | Chinese (231/429) | This study |
| DQB1*05 | Spontaneous clearance | USA (49/56) | 27 |
| DQB1*05:01 | Spontaneous clearance | USA (200/374) | 26 |
| DQB1*05:02 | Clearance | Italy (30 exposed but uninfected/116 HCV infected) | 45 |
| DQB1*05:02 | No association | Chinese (231/429) | This study |
| DRB1*11 | Clearance | Meta-analysis | 7 |
| Spontaneous clearance | Iran (54/63) | 38 | |
| SVR | Pakistan (150/54) | 36 | |
| Protective | USA (11,728 HCV uninfected/5901 HCV infected) | 34 | |
| Protective | Italy (70 HCV uninfected/73 HCV seropositive) | 39 | |
| DRB1*11:01 | Spontaneous clearance | UK (85/170) | 40 |
| Clearance | Meta-analysis | 37 | |
| DRB1*11:01 | Spontaneous clearance | Chinese (231/429) | This study |
| DRB1*15 | Spontaneous clearance | Ireland (86/141) | 24 |
| Spontaneous clearance | Germany (21/49) | 46 | |
| Persistence | Tunisia (24/75) | 47 | |
| DRB1*15:01 | No association | Chinese (231/429) | This study |
*The significance of the association in this study was determined by the results of logistic regression analysis.