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. 2016 Aug 11;6:31441. doi: 10.1038/srep31441

Figure 1. Treatment with CDK9 inhibitors ameliorates collagen induced arthritis.

Figure 1

(A) Kaplan-Meier plots showing onset of arthritis during treatment with 10 mg/kg CDK9 inhibitors (PC585, n = 10 and PC579 n = 10), 100 ug anti-TNF treatment (Enbrel, n = 10) or untreated controls (n = 10). (B) Development of clinical signs of arthritis during the course of experiment. (C) Histological evaluation of synovitis and (D) erosions in joints (Controls, n = 10; PC585, n = 10; PC579, n = 9; Enbrel, n = 9). (E) Serum levels of IgG fraction of antibodies against CII at end of experiment (Controls, n = 10; PC585, n = 10; PC579, n = 9; Enbrel, n = 9). (F) Representative histological changes in the front paw joints of animals treated with PC585 and non-treated controls. Horizontal line and error bars represent the mean and SEM, respectively. Box and whiskers graphs show median and min to max values. Differences between groups were analyzed using log-rank test, two-way ANOVA or one-way ANOVA with Bonferronion post-test. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.