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. 2016 Aug 11;6:31209. doi: 10.1038/srep31209

Table 4. The top canonical pathways and the genes from our dataset after functional enrichment of the genes obtained from expression pairing in IPA.

Canonical pathways ↓Down ↑Up −log(p-value) Genes miR:RNA-seq Target Molecules (total # of significant mRNAs in pathway from RNA-seq)
α-tocopherol Degradation 2/4 (50%) 0/4 (0%) 4.22E00 2 CYP4F3, CYP4F2
Allograft Rejection Signaling 0/73 (0%) 4/73 (5%) 4.06E00 4 HLA-DQA1, HLA-DRB3, PRF1, GZMB
Dendritic Cell Maturation 0/176 0% 5/176 (3%) 3.61E00 5 STAT4, HLA-DQA1, HLA-DRB3, PLCH2, CD1C
Graft-versus-Host Disease Signaling 0/46 (0%) 3/46 (7%) 3.37E00 3 HLA-DQA1, PRF1, GZMB
Autoimmune Thyroid Disease Signaling 0/47 (0%) 3/47 (6%) 3.34E00 3 HLA-DQA1, PRF1,GZMB
Granzyme B Signaling 0/16 (0%) 2/16 (13%) 2.93E00 2 PRF1, GZMB
T Helper Cell Differentiation 0/69 (0%) 3/69 (4%) 2.86E00 3 STAT4, HLA-DQA1, TBX21
Basal Cell Carcinoma Signaling 0/72 (0%) 3/72 (4%) 2.8E00 3 WNT3, HKR1, WNT10B
Axonal Guidance Signaling 0/432 (0% 6/432 (1%) 2.6E00 6 WNT3, SEMA6B, PLCH2, HKR1, ADAMTS1, WNT10B
Role of MΦ, Fibroblasts and Endothelial Cells in RA 1/297 (0%) 4/297 (1%) 2.59E00 5 WNT3, F2RL1, CCL5, PLCH2, WNT10B
Tumoricidal Function of Hepatic Natural Killer Cells 0/24 (0%) 2/24 (8%) 2.58E00 2 PRF1, GZMB
Communication between Innate and Adaptive Immune Cells 0/91 (0%) 3/91 (3%) 2.51E00 3 CD8A, CCL5, HLA-DRB3
Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells 0/32 (0%) 2/32 (6%) 2.33E00 2 PRF1, GZMB
Type I Diabetes Mellitus Signaling 0/108 0% 3/108 (3%) 2.3E00 3 HLA-DQA1, PRF1, GZMB
Antigen Presentation Pathway 0/37 (0%) 2/37 (5%) 2.21E00 2 HLA-DQA1, HLA-DRB3
Complement System 0/37 (0%) 2/37 (5%) 2.21E00 2 C1QB, C1QA
Choline Degradation I 0/2 (0%) 1/2 (50%) 2.2E00 1 CHDH
Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses 0/125 (0%) 3/125 (2%) 2.13E00 3 CCL5, C1QB, C1QA
Human Embryonic Stem Cell Pluripotency 0/133 (0% 3/133 (2%) 2.06E00 3 WNT3, WNT10B, S1PR5
Glioblastoma Multiforme Signaling 0/146 0% 3/146 (2%) 1.95E00 3 WNT3, PLCH2, WNT10B
Role of IL-17A in Arthritis 0/54 (0%) 2/54 (4%) 1.89E00 2 CCL5, CXCL3 (of 6)
Dopamine-DARPP32 Feedback in cAMP Signaling 1/161 (1%) 2/161 (1%) 1.83E00 3 KCNJ2, PPP1R14A, PLCH2
Protein Citrullination 1/5 (20%) 0/5 (0%) 1.8E00 1 PADI2
PCP pathway 0/63 (0%) 2/63 (3%) 1.76E00 2 WNT3, WNT10B
Granulocyte Adhesion and Diapedesis 0/177 (0% 3/177 (2%) 1.72E00 3 CCL5, CXCL3, CXCL2
Agranulocyte Adhesion and Diapedesis 0/189 (0% 3/189 (2%) 1.65E00 3 CCL5, CXCL3, CXCL2
OX40 Signaling Pathway 0/76 (0%) 2/76 (3%) 1.61E00 2 HLA-DQA1, HLA-DRB3

The rankings are based on the p values, starting with the lowest.