Table 3. Combined effects of three SNPs on non-syndromic orofacial cleft.
| Protective allele numbera | Case (%) | Control (%) | OR (95%CI) | P |
|---|---|---|---|---|
| 0 | 118 (20.59) | 77 (13.05) | Reference | |
| 1 | 220 (38.39) | 214 (36.27) | 0.67 (0.48–0.95) | 0.023 |
| 2 | 170 (29.67) | 210 (35.59) | 0.53 (0.37–0.75) | <0.001 |
| 3–6 | 65 (11.34) | 89 (15.08) | 0.48 (0.31–0.73) | <0.001 |
| 1–6 | 455 (79.41) | 513 (86.95) | 0.58 (0.42–0.79) | <0.001 |
| Pb < 0.001 | ||||
| 2 vs. 1 | — | — | 0.78 (0.59–1.03) | 0.083 |
| 3–6 vs. 2 | — | — | 0.91 (0.62–1.33) | 0.653 |
| 3–6 vs. 1 | — | — | 0.71 (0.49–1.04) | 0.081 |
ars1048201-T, rs3733336-G and rs546782-T were assumed as protective alleles based on the association study in Table 2.
bP value of multi degree-of-freedom likelihood ratio test.