Table 2. Example of manually curated interactors.
| Uniprot ID | Gene Name | pVHL Surface | pVHL interacting residues | Interacting protein residues or domain | Associated disease | Curator |
|---|---|---|---|---|---|---|
| P45973 | CBX5 | B | PXVXL motif, β-domain | RCC, PH, HB | F. S., G. M. | |
| P42771 | CDKN2A | N-terminal Domain | F. S., G. M. | |||
| Q6N084 | DKFZp686L11144 | RCC | F. S., G. M. | |||
| P02751 | FN1 | E. L. | ||||
| P49841 | GSK3B | Modification | Ser68 | E. L. | ||
| Q13547 | HDAC1 | RCC | F. S., G. M. | |||
| Q92769 | HDAC2 | Disordered | F. S., G. M. | |||
| P14866 | HNRNPL | C | F. S., G. M. | |||
| Q02363 | ID2 | A | 154–174 | F.Q., G.M. | ||
| Q92845 | KIFAP3 | D | 1–54 | E. L. | ||
| O43474 | KLF4 | 61–108 | CCC | F. S., G. M. | ||
| P33993 | MCM7 | F. S., G. M. | ||||
| Q9BQG0 | MYBBP1A | Pro693 | F. S., G. M. | |||
| Q8TEW0 | PARD3 | RCC | F. S., G. M. | |||
| Q8N2W9 | PIAS4 | B1/B2 | 54–120, β-domain | Carboxyl 46 amino acids | RCC | F. S., G. M. |
| A2A3R6 | RPS6 | F. S., G. M. | ||||
| P61758 | VBP1 | 87–213 | E. L. | |||
| O14709 | ZNF197 | 55–214 | KRAB-A domain | F. S., G. M. |
For each pVHL-interacting protein, Uniprot ID, Hugo name, interaction details, disease associated with interaction disruption, curators and their affiliation are reported. List of abbreviations for the disease column: CC, colorectal cancer, RCC, renal cell carcinoma. List of abbreviations for the curators column: F.S., F. Sundus, F.Q., F. Quaglia, G.M., G. Minervini, E. L., E. Leonardi.