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Main WNT/β-catenin pathway involved in cancer and stem cells. Wnt inhibits CTNNB1 phosphorylation by GSK3B, which leads to the transcription of pro-proliferation related genes via binding of CTNNB1 to TCF or LEF. P indicates phosphate. Red color shows molecules in pathways in cancer, whereas blue color shows molecules in signaling pathways regulating pluripotency of stem cells (KEGG). DVL: Dishevelled; TCF: T cell transcription factor; APC: Adenomatous polyposis coli.
