Skip to main content
. Author manuscript; available in PMC: 2016 Aug 11.
Published in final edited form as: J Med Chem. 2015 Dec 4;58(24):9722–9730. doi: 10.1021/acs.jmedchem.5b01510

Table 4.

Inhibition of [3H]TCP Binding at the PCP Binding Site by Substituted N-(2-(Chloro-5-alkylthiophenyl)-N′-(3-(trifluoromethyl)phenyl)-N′-methylguanidines

graphic file with name nihms808087u5.jpg
ligand R inhibition (%)a
36b Me 96.1
41 Et 86.4
42 Pr 62.1
43 Bu 82.7
44 iPr 22.6
45 sBu 48.8
46 CH2F 57.5
47 CH2CH2F 82.1
48 Bn 88.6
a

At 1.0 μM (mean from two experiments).

b

From Table 3; shown for ease of comparison.