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. Author manuscript; available in PMC: 2016 Aug 11.
Published in final edited form as: J Med Chem. 2015 Dec 4;58(24):9722–9730. doi: 10.1021/acs.jmedchem.5b01510

Table 5.

Inhibition of [3H]TCP Binding at the PCP Binding Site by Substituted N-(2-(Chloro-5-(trifluoromethyl)phenyl)-N′-(3-(trifluoromethyl)phenyl)-N′-methylguanidines

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ligand R inhibition (%)a
49 71.2
50 2-F −8.7
51 4-F 21.1
52 5-F 43.2
53 6-F 84.8
54 5-Br 99.0
55 6-Br 93.0
56 4-Me 42.3
57 5-Me 66.4
58 6-Me 38.0
59 5-CF3 46.2
a

At 1.0 μM (the mean from two experiments).