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. 2016 Aug 11;6:31549. doi: 10.1038/srep31549

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Copyright © 2016, The Author(s)

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(a) Upstream regulators TLR4 (FC 2.566, z-score = 2.344) and IL18 (FC −4.559, z-score = 2.025) predicted to have enhanced activity in light of the fold changes in the expression of their target genes. (b) Upstream regulators IL1A (FC −5.208, z-score = 1.985), IRF4 (FC −2.188, z-score = −1.969), and PRDM1 (FC −4.254, z-score = −1.698) with a strong trend toward significance, namely with z-scores close to ±2.