Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Aug 11;6:31538. doi: 10.1038/srep31538

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

(A) Representative images of the Comet Assay at 4X magnification in FLO-1 cells treated with or without TDCA treatment (10⁻¹¹ M,24 hours) in the presence or absence of NADPH oxidase inhibitor diphenyleneiodonium (DPI 10⁻⁵ M). (B) TDCA-induced increase in tail moment was significantly reduced by DPI (N = 149–208 cells of 3 experiments). (C) Typical images of Western blot analysis and (D) summarized data showed that TDCA (10⁻¹¹ M, 24 hours) significantly increased H2AX phosphorylation, an increase which was significantly decreased by DPI (N = 3). These data suggest that NADPH oxidases may be involved in TDCA-induced DNA damage. ANOVA **P < 0.0001, compared with control group; ^#P < 0.0001, *P < 0.05, compared with TDCA group.