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. 2016 Aug 11;6:31538. doi: 10.1038/srep31538

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(A) Knockdown of NOX5-S significantly decreased the tail moment in response to TDCA treatment in FLO-1 cells (N = 130–171 cells of 3 experiments). (B) Representative images of the Comet Assay at 4X magnification in FLO-1 cells transfected with pCMV or NOX5-S plasmid with or without TDCA treatment (10⁻¹¹ M, 24 hours). (C) Overexpression of NOX5-S significantly increased the tail moment in response to TDCA treatment in FLO-1 cells (N = 136–172 cells of 3 experiments). These data suggest that NOX5-S may mediate TDCA-induced DNA damage in FLO-1 cells. ANOVA **P < 0.01, compared with Control siRNA group or pCMV group; ^#P < 0.05, compared with Control siRNA group plus TDCA group or pCMV plus TDCA group.