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. 2016 Aug 11;6:31538. doi: 10.1038/srep31538

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Copyright © 2016, The Author(s)

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(A) Typical images of Western blot analysis and (B) summarized data showed that TDCA significantly increased H2AX phosphorylation, an increase which was significantly decreased by knockdown of NOX5-S (N = 3). (C) Typical images of Western blot analysis and (D) summarized data showed that overexpression of NOX5-S enhanced TDCA-induced increase in H2AX phosphorylation in FLO-1 cells (N = 3). These data suggest that NOX5-S may mediate TDCA-induced H2AX phosphorylation. ANOVA, *P < 0.05, compared with Control siRNA group or pCMV group; ^&P < 0.05, compared with Control siRNA plus TDCA group or pCMV plus TDCA group.