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. 2016 Aug 11;6:31538. doi: 10.1038/srep31538

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Copyright © 2016, The Author(s)

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(A) TDCA treatment (10⁻¹¹ M) significantly increased phosphorylation of CREB in a time-dependent manner in FLO-1 cells, indicating that TDCA may activate CREB. B) TDCA significantly increased NOX5-S mRNA levels, an increase which was significantly decreased by knockdown of CREB, suggesting that CREB may mediate TDCA-induced increase in NOX5-S expression. N = 4, ANOVA *P < 0.05, compared with Control siRNA group; **P < 0.02, compared with Control siRNA plus TDCA group.