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. 2016 Aug 11;6:31509. doi: 10.1038/srep31509

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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P4 activated the cSrc/AKT signaling pathway, which in turn induced activation of RSK1, subsequently causing p27 phosphorylation at T198 and increasing formation of the p27-RhoA complex, and eventually enhanced migration of breast cancer cells. P4 also activated the cSrc/ERK1/2 signaling pathway to induce IκBα activation and NFκB nuclear translocation, which in turn up-regulated the expression of RSK1 and p27. The increased expression of RSK1 and p27 are not required, but might have some degree of contributions, for the P4-induced migration enhancement in breast cancer cells.