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. 2016 Aug 11;6:31566. doi: 10.1038/srep31566

Figure 4. K14-VEGF-C mice show increased insulin resistance under HFD.

Figure 4

(a) Increased body weight and (b) SWAT %, while EWAT % remained unaltered in K14-VEGF-C mice under HFD. (c) Fasting blood glucose was significantly elevated in K14-VEGF-C mice. (d) Insulin tolerance test (n = 5 per group, mean ± SEM is shown, *p < 0.05 compared to WT control at the same time point with a two-tailed Student’s t-test). (e) Comparison of liver gross morphology, Oil Red O stained liver sections and quantification of triglyceride (TG) content of livers showing increased ectopic lipid accumulation in K14-VEGF-C mice on HFD. Representative western blots (f) and corresponding quantification (g) of phosho-AKT and AKT in liver lysates of WT and K14-VEGF-C mice. (h) Cross sections of adipose tissue samples showing that K14-VEGF-C mice on HFD had larger SWAT adipocytes. Liver gross morphology images scale bar = 1 cm, liver Oil Red O staining and adipose tissue cross-section scale bars = 100 μm. *p < 0.05 and **p < 0.01, two-tailed Student’s t-test. Data are mean ± SD.