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. 2015 Dec 13;2(2):222–237. doi: 10.1016/j.jcmgh.2015.12.001

Figure 1.

Figure 1

Claudin-1 is an early target for CRC. (A) From the GSE41258 gene expression data set, the mean (±SD) base-2 log level for claudin-1 was 4.8 ± 0.8 and 3.5 ± 0.4 for human adenomas (n = 45) and normal (n = 52) colonic mucosa, resulting in an average difference of 2.54-fold (P = 9.4 × 10-18) by 2-sample t test. On immunohistochemistry, minimal staining was observed from representative sections of (B) normal and (C) hyperplastic polyps. Intense cell surface staining (arrows) was seen in representative sections of (D) SSAs and (E) adenomas from human proximal colon specimens. By using a standard IHC scoring system, overexpression (2+/3+) of claudin-1 was found in 14% (4 of 28) of normal, 17% (2 of 12) of hyperplastic polyps, 73% (8 of 11) of SSAs, and 87% (26 of 30) of adenomas.