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Tight junction function and ZO-1 distribution are not altered by claudin-1 peptide. (A) Confluent T84 monolayers were incubated with either 5 μmol RTS* or SPT* (control), peptides show high TEER for up to 24 hours. Immunofluorescence shows localization of (B and E) anti–ZO-1 and (C and F) anti-CLDN1 antibodies on the apical plasma membrane of tight junctions at 24 hours after peptide incubation. (D) RTS* peptide partially localizes to cellular junctions.
