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. 2016 Aug 10;48:56. doi: 10.1186/s12711-016-0232-y

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Clinical and histological features of retinal degeneration in old Normande cows. a and b Eyes fundus from control RP1 Fs/Wt (a) and affected RP1 Fs/Fs (b) Normande cows. Arrows indicate hyperreflective areas and note the general reduction of the caliber of blood vessels in the affected animal. c and d Histological sections of the retina from the same control (c) and affected (d) animals. Note the total absence of inner and outer segments of photoreceptor cells and a marked thinning and disorganization of the outer nuclear layer confirming retinal degeneration in the Fs/Fs animal. (GCL ganglionic cells layer, IPL inner plexiform layer, INL inner nuclear layer, OPL outer plexiform layer, ONL outer nuclear layer, IS inner segment, OS outer segment. 5 µm sections of tissue embedded in paraffin and stained with HES. The choroid is not shown due to large artefactual gaps created by tissue preparation)