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(A) Known signalling pathways that affect Hsp90 expression. The co-activator Daxx is not shown in the scheme, but is known to promote the activation of HSF1 [69]. (B) Possible binding scenario for transcriptional activators and cofactors that regulate Hsp90 transcription. IFN-γ, interferon-γ; IL-R, interleukin receptor; JAK, Janus kinase; MAPK, mitogen-activated protein kinase.
