Table 4.

Univariate and multivariate regression models of factors predicting FFbF in men with pathologic Gleason ≤6 (low-grade disease) following radical prostatectomy at University of Pennsylvania, 1990–2012.

Univariate analysis	HR	95% CI	p-Value
Age	1.01	0.96 to 1.05	0.63
African-American Race	2.02	1.09 to 3.74	0.025
Serum PSA	1.22	1.06 to 1.41	0.005
T-stage	1.37	0.87 to 2.14	0.17
Clinical Gleason score	2.48	0.76 to 8.19	0.13
Year of prostatectomy	0.99	0.91 to 1.06	0.61
Extraprostatic spread	4.05	2.27 to 7,23	<0.001
Positive surgical margins	3.71	1.94 to 7.04	<0.001
Seminal vesicle invasion	8.1	2.87 to 22.8	<0.001
Multivariate analysis
Age	1.02	0.97 to 1.06	0.44
Year of prostatectomy	0.99	0.92 to 1.07	0.81
Clinical Gleason score	1.23	0.35 to 4.41	0.74
Serum PSA	1.24	1.15 to 1.34	<0.001
Extraprostatic spread	3.77	1.79 to 7.95	<0.001
African-American Race	2.01	1.08 to 3.72	0.029
Seminal vesicle invasion	2.71	0.89 to 8.57	0.089
Positive surgical margins	1.83	0.81 to 4.12	0.15

NOTE. Boldfaced values represent statistically signi cant differences between groups.

Abbreviations: PSA- Prostate-specific antigen, NCCN- National Comprehensive Cancer Network, FFbF- Freedom From biochemical Failure

P values derived from a Cox proportional hazards model.