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PDE5 inhibitory activity of 1, 3-disubstituted tetrahydro-β-carbolines (1–4) and the fully aromatic β-carboline 25.
| Compound | Chirality | PDE5 % inhibition at 10 μma) | PDE5 inhibition IC50 (μm) |
|---|---|---|---|
| 1 | 1S, 3R | <60 | ND |
| 2 | 1R, 3R | <60 | ND |
| 3 | 1R, 3S | <60 | ND |
| 4 | 1S, 3S | <60 | ND |
| 25 | NA | <60 | ND |
Calculated from triplicate values.
