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PDE5 inhibitory activity of tetrahydro-β-carboline-piperazinediones (23, 24).
| Compound | R | Chirality | PDE5 % inhibition at 10 μma) | PDE5 inhibition IC50 (μm)b) |
|---|---|---|---|---|
| 23 | C2H5 | 6S, 12aR | 81 | 1.71 |
| 24 | C2H5 | 6S, 12aS | 87 | 1 |
Calculated from triplicate values.
Calculated from 10 concentrations, each with double replicates.
