Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
IC50 (μm)a) of the most active tetrahydro-β-carboline-hydantoins and tadalafil against an array of PDEs.
| Compound | PDE1A cGMP | PDE2A cGMP | PDE3A cGMP | PDE5A cGMP | PDE9A cGMP | PDE10A cGMP | PDE11A cGMP | PDE11A cAMP | Selectivity index IC50 (PDE11A/PDE5A) cGMP/cGMP |
|---|---|---|---|---|---|---|---|---|---|
| 8 | >50 | >50 | >50 | 0.16 | >50 | >50 | 7.8 | 11.3 | 49 |
| 9 | >50 | >50 | >50 | 0.17 | >50 | >50 | 2.3 | 4 | 14 |
| Tadalafil | >50 | >50 | >50 | 0.004 | >50 | >50 | 0.05 | 0.3 | 13 |
Calculated from 10 concentrations, each with double replicates.
