Table 1.

Histological assessment criteria for renal damage (adapted from Rolleman et. al, EJNMMI 2007 [16])

Grade	Overview	Glomeruli	Tubules
Mild	More or less normal aspect	Apoptosis of endothelium cells	Apoptotic cells
	High glomerular cell count	Inflammatory infiltrate	Rough protein staining
			Little dilation
			Normal basal membrane
			No proteine cylinders
Moderate	Tubular dilation	Same as grade 1	More apoptotic cells
	Tubular cell damage		More pronounced dilation
			Thickened basal membrane
			Little tubular protein cylinders
			Regenerating cells (mitotic activity)
Pronounced	Stronger tubular dilation	Smaller vascular lumina, few erythrocytes	Flat epithelium
	Cell-rich infiltrate		Partly, complete loss of epithelium
	Regenerating tubules		Stronger dilation
			Inflammatory infiltrate
			Regeneration present
			More thickened basal membrane
Severe	Severe tubular dilation	Same as grade 3	Same as grade 3, but more empty cylinders
		More optical empty space due to glomerular shrinkage	Peripheral fibrosis