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. Author manuscript; available in PMC: 2016 Aug 11.
Published in final edited form as: J Alzheimers Dis. 2016 Apr 8;52(4):1263–1275. doi: 10.3233/JAD-160033

Table 3.

Ligand Binding in the Thyroxine-binding Pocket of Transthyretin (TTR)

Property Small Molecules Proteins
Molecule Thyroxine (T4) Tafamidis Aβ1-40/42 C99
Kd 15nM 2nM 24µM 85µM
Stoichiometry 1–2 1–2 1 1
TTR binding
site 		K15, L17,
T106, A109,
L110, T119,
S117		 K15, L17,
E54, T106,
A109, L110,
S117, T119		 K15, L17, A109,
L110, A120,
V121,V122,M13,V16,
A19, N27		 L12, M13,
V14, V16,
R104, v123