Figure 1.
Representative record of effects of L-NAME and ARL-17477 on spontaneous motor contractions of colonic tissues isolated from control and IBS-rats. L-NAME significantly increased the mean pressure in both control (a) and IBS (b) groups at concentration of 10−4 mol/L (P < 0.05). ARL-17477 significantly increased the mean pressure on only in the control (c) group at concentrations of 10−7 and 10−6 mol/L (P < 0.05); did not increase significant in IBS (d) group (P > 0.05). IBS: Irritable bowel syndrome