Figure 4.

Magnetic resonance imaging of the brain in x-linked adrenoleukodystrophy: (a) T2-weighted axial image shows bilateral confluent symmetrical white matter hyperintensity in the parieto-occipital region with involvement of the splenium (b,c) T1-weighted axial and saggital image with contrast-enhancement shows the classical three zones: zone of active demyelination without inflammation (*), zone of prominent inflammation (white arrow) and zone of completely demyelinated/burnt-out areas (^). FLAIR axial images of another child (d-f) Shows selective corticospinal tract involvement from cortex to internal capsule with mild parieto-occipital involvement