Figure 3.

Structures of replication initiation proteins: (A) bacterial DnaA protein and (B) RepE protein from plasmid F. (A) Crystal structure of Domain I (shown in violet) of EcDnaA protein was obtained from the PDB database (2E0G). Domain III (shown in blue) and Domain IV (shown in red) were modeled using SWISS-MODEL server (http://swissmodel.expasy.org) basing on crystal structure of Domain IV obtained from PDB database (1J1V). The presented structure of EcDnaA does not include Domain II. (B) Crystal structure of RepE protein, comprising Winged Helix domain 1 (WH1), and Winged Helix domain 2 (WH2) (shown in yellow and green, respectively), were obtained from the PDB database (1REP).