Figure 3.

Amino acid sequence of CopR and 3D model of the CopR-DNA complex. (A) Model of the CopR-DNA complex. Green and red, CopR monomer I and II, respectively. Blue, DNA bottom strand. Yellow, DNA top strand. Gray, aa forming the hydrophobic core (for reasons of clarity shown only for monomer I). Orange, aa at the dimeric interface, shown only for monomer II. The presented DNA conformation is speculative. (B) Amino acid sequence of CopR (Brantl et al., 1994). Predicted α-helices are shown as gray boxes and numbered above the boxes. Red-framed box, DNA recognition helix. Red letters, aa involved in specific DNA recognition. Blue letters, aa predicted and shown to be involved in dimerization. Green letters, alternating hydrophobic and hydrophilic aa at the C-terminus forming a β-strand that stabilizes CopR.