Table 1.

The number, mean, median, and different middle percentile ranges of drugs in our approved and discontinued‐drug database.

		No. of	Mean MP	Mean MP	Minimum and maximum MPs [°C] (within given percentiles)[a]
Drug class	State	drugs	[°C]	[°C]	0–100th	5th–95th	10th–90th	15th–85th	20th–80th	25th–75th
All	approved	3164	162	160	25–386	60–268	80–244	95–231	108–217	117–205
	discontinued	417	171	169	25–371	70–265	96–251	110–238	119–226	129–214
Oral	approved	683	168	166	25–350	74–265	94–244	108–232	115–219	126–209
	discontinued	93	173	173	56–290	86–249	102–245	114–237	126–218	133–210
CNS	approved	511	145	143	25–316	53–239	71–218	83–204	96–191	105–181
	discontinued	80	173	168	50–310	102–282	116–239	120–226	127–214	131–210
Non‐CNS	approved	2346	168	165	25–386	66–268	85–249	100–234	112–222	122–212
Anticancer	approved	211	179	181	32–354	69–283	96–261	108–234	118–229	136–219
Anti‐infective	approved	428	182	181	37–350	87–280	104–260	121–245	131–232	146–220
Cardiovascular	approved	400	154	152	25–345	54–263	71–243	85–223	100–212	110–196

[a] From the smallest to largest MPs of all drugs, min. and max. MPs (5–95th percentiles) represent the largest MP in the top 5 % low MPs (min.), and the smallest MP in the bottom 5 % high MPs (max.), respectively. The rest (10^th–90^th, 15^th–85^th, 20^th–80^th, and 25^th–75^th percentiles) could be deduced by analogy.