TABLE I. The characteristics of different experimental infections of Phlebotomus perniciosus by LUC - Leishmania infantum .
| Experimental model | Promastigote load | Experimentation | Fed sand flies(%) | Leishmania positive sand flies/Fed sand flies | Average Leishmania number (extremes) | |||
|---|---|---|---|---|---|---|---|---|
| Artificial feeder | 1.107/mL of blood | 1 | 57/150 (38%) | 75/270 (28%) | 32/57 (56%) | 44/75 (59%) | 32015 (11-287573) | 50551 (11-481978) |
| 2 | 18/120 (15%) | 12/18 (66%) | 99982 (125-481978) | |||||
| 2.106/mL of blood | 1 | 10/200 (5%) | 57/800 (7%) | 4/10 (40%) | 22/57 (39%) | 134 (10-458) | 6487 (10-65825) | |
| 2 | 12/200 (6%) | 4/12 (33%) | 129 (18-341) | |||||
| 3 | 20/200 (10%) | 9/20 (45%) | 6322 (20-65825) | |||||
| 4 | 15/200 (7.5%) | 5/15 (33%) | 11300 (256-34801) | |||||
| Murin model | 2.108 (IV route) | Mouse 1 (8 week post infection) | 17/120 (14%) | 428/ 1840 (23%) | / | 1/428 (0.2%) | / | 11 |
| Mouse 1 (10 week p.i) | 15/200 (7.5%) | / | / | |||||
| Mouse 1 (11 week p.i) | 10/200 (5%) | / | / | |||||
| Mouse 2 (8 week p.i) | 58/120 (48%) | / | / | |||||
| Mouse 2 (11 week p.i) | 21/200 (10.5%) | / | / | |||||
| Mouse 3 (21 week p.i) | 16/200 (8%) | / | / | |||||
| Mouse 3 (30 week p.i) | 29/200 (14.5%) | / | / | |||||
| Mouse 4 (2 week p.i) | 147/200 (78%) | 1/147 (0.7%) | 11 | |||||
| Mouse 4 (2 week p.i) | 67/200 (33.5%) | / | / | |||||
| Mouse 5 (2 week p.i) | 48/200 (24%) | / | / | |||||