Skip to main content
. 2016 Jan 25;10(1):83–91. doi: 10.1080/19336896.2015.1118603

FIGURE 1.

FIGURE 1.

Investigating the structural determinants of the CWD-human transmission barrier. The human and elk β2-α2 loop amino acid sequences differ at 4 positions: 166, 168, 170, and 174 (top). Transgenic mice expressing full-length human PrPC (blue) or human PrPC with the elk β2-α2 loop (red) were inoculated intracerebrally with CWD prions. Although mice expressing human PrPC did not develop disease, mice expressing the human-elk loop PrPC [Tg(HuPrPelk166-174)] were susceptible to CWD infection (83%). Inoculation of brain from a CWD-infected Tg(HuPrPelk166-174) mouse into additional transgenic mice transmitted the disease to all Tg(HuPrPelk166-174) mice, but to only 1 of 17 Tg(HuPrP) mice.