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. 2016 Mar 10;10(2):119–126. doi: 10.1080/19336896.2016.1141860

FIGURE 1.

FIGURE 1.

Cell surface receptors responsible for macropinocytosis and protein aggregate recognition. A) Receptor tyrosine kinases (RTK), integrins (INT) and heparan sulfate proteoglycans (HS) have been associated with the viral particle recognition and subsequent triggering of macropinocytosis. B) Scavenger receptors (SR), RAGE, integrins (INT), CD14 and toll like receptors (TLR) have all been found to play a role in recognition and subsequent proinflammatory response to protein aggregates of amyloid β peptide. C) Neurons have been shown to express scavenger receptors (SR), receptor tyrosine kinases (RTK), integrins (INT) and heparan sulfate proteoglycans which may be involved in triggering of macropinocytosis by protein aggregates.