TABLE 2.

Functional categories^* overrepresented in the subset of Q/N-rich proteins^** in comparison with the entire proteome of S. cerevisiae

Function	Total number of proteins in category	Number of Q/N-rich proteins	The level of significance
GO:0004674 protein serine threonine kinase activity	128	29	0.05
GO:0004713 protein tyrosine kinase activity	8	4	0.028455
GO:0016251 general RNA polymerase II transcription factor activity	72	20	0.05
GO:0005515 protein binding	486	62	0.04775
GO:0003702 RNA polymerase II transcription factor activity	147	50	0.05
GO:0030276 clathrin binding	13	6	0.047577
GO:0016563 transcription activator activity	50	26	0.05
GO:0016564 transcription repressor activity	39	16	0.05
GO:0004672 protein kinase activity	134	30	0.05
GO:0003723 RNA binding	442	56	0.04131
GO:0046914 transition metal ion binding	398	62	0.05
GO:0019899 enzyme binding	38	9	0.026086
GO:0016773 phosphotransferase activity alcohol group as acceptor	196	34	0.05
GO:0016566 specific transcriptional repressor activity	21	7	0.0416
GO:0001071 nucleic acid binding transcription factor activity	137	50	0.05
GO:0019208 phosphatase regulator activity	26	10	0.05
GO:0019888 protein phosphatase regulator activity	26	10	0.05
GO:0016301 kinase activity	222	34	0.047667
GO:0003704 specific RNA polymerase II transcription factor activity	56	24	0.05
GO:0019789 SUMO ligase activity	5	3	0.013763
GO:0030234 enzyme regulator activity	256	41	0.05
GO:0035091 phosphoinositide binding	66	16	0.048875
GO:0004535 poly(A)-specific ribonuclease activity	5	3	0.013763
GO:0008289 lipid binding	95	23	0.05
GO:0030528 transcription regulator activity	279	88	0.05
GO:0043565 sequence-specific DNA binding	261	77	0.05
GO:0008143 poly(A) RNA binding	7	4	0.038469
GO:0008270 zinc ion binding	313	56	0.05
GO:0060589 nucleoside-triphosphatase regulator activity	131	20	0.006615
GO:0070717 poly-purine tract binding	7	4	0.038469
GO:0008601 protein phosphatase type 2A regulator activity	5	3	0.013763
GO:0003729 mRNA binding	52	22	0.05
GO:0003727 single-stranded RNA binding	15	7	0.0482
GO:0016455 RNA polymerase II transcription mediator activity	30	8	0.029088
GO:0003700 sequence-specific DNA binding transcription factor activity	137	50	0.05
GO:0005543 phospholipid binding	84	21	0.05

^*Functional analysis of the subset was performed in the “Gene Ontology” Database (http://www.geneontology.org/); fractions of proteins were compared by “GoMiner” software.

^**The selection of Q/N-rich proteins from the S. cerevisiae proteome was obtained using the SARP algorithm.¹⁷⁹ The probability thresholds were set to 10⁻⁶ for single residue CBRs and 10⁻¹² for multiple residue CBRs; CBRs were detected for the N and Q residues, as well as for the Q/N pair.