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PrPse propagation in the CNS. Schematic representation of the propagation of PrPsc in neuronal cells of the CNS. PrPSc acquired by infection, mutation or spontaneous conversion of cellular PrP (PrPC) combines with PrPc thereby converting it to PrPC is recruited and converted ti PrPSc. As PrPSc levels increase PrPC recruitment and conversion become more efficient, leading to an accumulation of PrPSc in neuronal cells. PrPSc accumulation causes cell dysfunction followed by death.
