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Schematic representation of the protein structure and the proteolytic processing of the PrPC in human cells. (A) Whole PrPC moleule. Post-translational modification is initiated by the removal of N-terminal and C-terminal signal p eptides. (B) Normal constitutive cleavage occurring in brain and culture cells. (C) β-cleavage mediated by reactive oxygen species (ROS). (D) Ecotodomain Shecking of the PrPC where nearly whole PrPc molecule is released from the cellular membrane.
