Table 5.
Analysis of risk factors for freedom from rejection using a Cox proportional hazard model
| Variable | Univariate | Multivariable | ||
|---|---|---|---|---|
|
|
|
|||
| HR (95% CI) | p-value | HR (95% CI) | p-value | |
| Categorical variables | ||||
|
| ||||
| Sex (male) | 1.16 (0.54–2.54) | 0.701 | ||
|
| ||||
| Donor sex (male) | 0.88 (0.43–1.81) | 0.735 | ||
|
| ||||
| Diagnosis | ||||
|
| ||||
| Non-CMP (ref: CMP) | 0.51 (0.18–1.44) | 0.204 | ||
|
| ||||
| Preoperative mechanical ventilation | 0.29 (0.07–1.21) | 0.090 | ||
|
| ||||
| Preoperative mechanical circulatory support | 0.45 (0.16–1.27) | 0.130 | ||
|
| ||||
| Diabetes mellitus | 1.05 (0.51–2.15) | 0.905 | ||
|
| ||||
| Hypertension | 0.63 (0.31–1.27) | 0.198 | ||
|
| ||||
| History of cerebrovascular accident | 1.22 (0.48–3.11) | 0.682 | ||
|
| ||||
| Dyslipidemia | 0.87 (0.36–2.07) | 0.751 | ||
|
| ||||
| Chronic kidney disease | 0.25 (0.08–0.81) | 0.021 | ||
|
| ||||
| Coronary artery disease | 0.57 (0.25–1.29) | 0.175 | ||
|
| ||||
| History of cardiac surgery | 0.89 (0.39–2.02) | 0.784 | ||
|
| ||||
| Immunosuppressive regimen | <0.001 | <0.001 | ||
|
| ||||
| Cyclosporine+MMF+Pd (ref: cyclosporine+AZA+Pd) | 0.17 (0.07–0.43) | <0.001 | 0.12 (0.97–1.00) | <0.001 |
|
| ||||
| Tacrolimus+MMF+Pd (ref: cyclosporine+AZA+Pd) | 0.09 (0.05–0.20) | <0.001 | 0.12 (0.06–0.27) | <0.001 |
|
| ||||
| BMI (kg/m2) | 0.355 | |||
|
| ||||
| <18.5 (ref: 18.5≤BMI<23) | 0.43 (0.13–1.42) | 0.165 | ||
|
| ||||
| ≥23 (ref: 18.5≤BMI<23) | 1.02 (0.52–2.00) | 0.948 | ||
|
| ||||
| Continuous variables | ||||
|
| ||||
| Age (yr) | 0.97 (0.95–0.99) | 0.009 | ||
|
| ||||
| Donor age (yr) | 0.97 (0.94–1.00) | 0.034 | ||
|
| ||||
| Donor ischemic time (min) | 0.99 (0.99–1.00) | 0.074 | ||
|
| ||||
| Recipient aortic cross-clamp time (min) | 0.98 (0.96–0.99) | 0.002 | ||
|
| ||||
| Recipient cardiopulmonary bypass time (min) | 0.99 (0.98–0.99) | <0.001 | ||
HR, hazard ratio; CI, confidence interval; CMP, cardiomyopathy; ref, reference; MMF, mycophenolate mofetil; Pd, prednisone; AZA, azathioprine; BMI, body mass index.