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Problem space of known drug-drug interactions (DDIs). A) DDI network consisting of 1,441 nodes and 45,530 edges (our unpublished data). B) A maximized region of known DDIs network. C) DDIs network of prednisolone with other drugs (about 92 different drug substances). Data were produced by means of Cytoscape ver. 3.3.0 freely available at: http://www.cytoscape.org/. Drug-drug interaction information was collected from the Canadian drug bank freely available at: http://www.drugbank.ca/.
